منابع مشابه
Hepatitis B Virus Reactivation Associated With Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus.
Background: Direct-acting antiviral agents (DAAs) are used increasingly to treat hepatitis C virus (HCV) infection. Reports were published recently on hepatitis B virus (HBV) reactivation (HBV-R) in patients with HBV–HCV co-infection. Hepatitis B virus reactivation, defined as an abrupt increase in HBV replication in patients with inactive or resolved HBV infection, may result in clinically sig...
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Research produces highly efficient antiviral drugs. At the same time, viruses develop sophisticated strategies to evade their actions. Resistance to antiviral therapy has become a major issue in the management of patients with chronic viral infections. The best known example is human immunodeficiency virus (HIV), but cytomegalovirus, herpes simplex virus, and hepatitis B and C viruses exhibit s...
متن کاملAntiviral Therapy in Elderly Patients With Hepatitis C Virus Infection.
The emergence of direct-acting antiviral (DAA) agents has revolutionized the treatment schema for hepatitis C virus (HCV) infection. From cure rates to tolerability, DAA agents have shown outstanding profiles compared with the prior therapy of pegylated interferon with ribavirin. However, the efficacy and safety profiles of DAA therapy in older patients, particularly the elderly, have been uncl...
متن کاملTargets for antiviral therapy of hepatitis C.
Presently, interferon- (IFN-) containing treatment regimens are the standard of care for patients with hepatitis C virus (HCV) infections. Although this therapy eliminates the virus in a substantial proportion of patients, it has numerous side effects and contraindications. Recent approval of telaprevir and boceprevir, targeting the protease residing in nonstructural protein 3 (NS3) of the HCV ...
متن کاملPlugging the holes in hepatitis C virus antiviral therapy.
A growing number of RNA viruses are now known to depend on virus-encoded ion channels for efficient production of infectious virions and, in some cases, for the subsequent infection of naı̈ve cells. So-called viroporins are small hydrophobic proteins, usually less than 100 aa in length, and typically contain 1 or 2 transmembrane domains (TMDs); oligomerization is therefore necessary for the form...
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ژورنال
عنوان ژورنال: Journal of Nihon University Medical Association
سال: 2008
ISSN: 0029-0424,1884-0779
DOI: 10.4264/numa.67.332